Wilson piloted a struggling Denver offense through the first two games of the season, an underwhelming start to his Broncos career coming after they traded five draft picks, including two first-rounders, and three players to acquire him from the Seattle Seahawks.
Then handed a five-year, $245million extension by the Broncos, Wilson lost in Week 1 on an emotional return to Seattle, before the Denver offense was jeered and mocked by its own home fans in Week 2 in an unconvincing win over the Houston Texans.
Wilson and the Broncos struggled for most of their win over the 49ers against a ferocious San Francisco defense that held the quarterback to 184 yards passing and Denver to just 3.7 yards per play.
But the 49ers' ineptitude on offense in Jimmy Garoppolo's first start since Trey Lance's season-ending injury saw San Francisco waste a host of opportunities to take command, the Niners going one for 10 on third down.
And Wilson finally capitalised on their profligacy in the fourth quarter, showing some of his trademark elusiveness that some believed may be waning to lead a 12-play, 80-yard drive and give the Broncos a decisive 11-10 lead.
Garoppolo was intercepted on the subsequent drive, and a Jeff Wilson Jr. fumble then sealed the game for Denver.
"Russell has come to a new state, a new organisation, with 10 brand new guys in the huddle," Hackett told NBC Sports' Peter King for his Football Morning in America column.
"It's a completely new look, new team. He's jumped in here and tried to make it as familiar as he could. On that winning drive, he said, 'I'm comfortable, I'm gonna use my legs here, I've got to make this happen'. He did. Hopefully that's the start of it for him."
Hackett's game management came under severe scrutiny in the opening two weeks of his tenure as Denver head coach, his struggles in that regard encapsulated by the home crowd counting down the play clock in Week 2 after his offense had struggled to get the ball snapped in time on several plays.
Ahead of Week 3, Hackett brought in veteran assistant coach Jerry Rosburg to help with gameday decisions.
Asked if doing so felt embarrassing, Hackett said: "No. For me, I felt empowered that I was able to make a decision. Hey, let's fix it. I'm the leader of the team. Let’s do it.
"This was the first time, the past two games, that I felt I was hurting my team. Did I have enough info? I don't know. But I knew the setup wasn't right. I needed help to make the tough decision."