Luckless Bulls fly-half Handre Pollard has been ruled out for up to 10 weeks after damaging his ankle in training on Thursday.
The South Africa international's chances of playing in the Test series against France in June would appear to be slim following his latest injury setback.
Pollard missed the entire 2016 Super Rugby season due to knee and shoulder injuries, but made his comeback in February.
The 23-year-old playmaker may require surgery after suffering another setback, which is expected to rule him out for eight to 10 weeks.
Pollard, the Springboks' first-choice fly-half at the 2015 Rugby World Cup in England, last year revealed he was told he could lose an arm due to complications with surgery after his shoulder became badly infected.
South Africa face Les Blues in Pretoria on June 10 for the first of three Tests.