In Markus Gisdol's first match in charge of Hoffenheim, Roberto Firmino got the new regime off to a great start when he opened the scoring for the hosts on 11 minutes.
The Brazilian exchanged passes with Sven Schipplock before firing in off the underside of the bar.
Dusseldorf grew into the encounter but Hoffenheim held firm and doubled their tally on 75 minutes courtesy of an Andreas Lambertz headed own goal.
That took the steam out of the visitors and Hoffenheim added a gloss to the scoreline four minutes into time added on when Kevin Volland rounded the keeper and slotted into an empty net.
Hoffenheim remain second bottom in 17th, but the victory takes them onto 23 points, just one behind Augsburg.
Dusseldorf are 15th, five points ahead of Augsburg.
The bottom two will be relegated at the end of the season while the team in 16th contest a play-off.
- Sports & Recreation
- Sven Schipplock