Schalke coach Huub Stevens could also be without teenager Julian Draxler and Christoph Metzelder, who got a knock on his knee in training on Wednesday.
Draxler broke his arm earlier this month and is wearing a cast.
"If Julian does not have problems with it then he could be in the squad," said Stevens.
Dortmund are also missing a talismanic playmaker in Mario Goetze.
Schalke are third on 14 points with Dortmund, whose playmaker Mario Goetze return injured from international duty, two points behind in fourth.
- Huub Stevens
- Christoph Metzelder
- Julian Draxler