There is also a Champions League debut for young defender Calum Chambers, who joined from Southampton for £16m in the summer.
Arsenal's World Cup winning Germany stars Mesut Ozil, Lukas Podolski and Per Mertesacker are again rested as Arsene Wenger gives them time off following their exploits in Brazil.
ARSENAL XI: Szczesny, Debuchy, Chambers, Koscielny, Monreal, Arteta, Wilshere, Ramsey, Alexis, Cazorla, Giroud
- Sports & Recreation
- Calum Chambers
- Yaya Sanogo
- Manchester City
- Lukas Podolski
- Arsene Wenger