Los Blancos go to Signal Iduna Park for the second leg of their Champions League quarter-final, holding a 3-0 advantage.
But they are to do so without the Portugal international, who left training 20 minutes in on Monday complaining of knee trouble.
The Ballon d’Or winner was rested for Madrid’s 4-0 win over Real Sociedad at the weekend, but that was initially seen as just a precaution.
However, after his left knee flared up again, it looks as if Ronaldo will sit out the Champions League clash tonight.
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