Kevin Davies struck after 93 seconds against his former club in a first half dominated by Wanderers.
Eagles was a constant menace alongside Jacob Butterfield and Lee Chung-Yong, the attacking trio operating behind a typically robust and effective Davies.
Butterfield, Lee and Davies were recalled as three of six changes made by Whites boss Dougie Freedman, but his alterations soon looked inspired and Blackburn had goalkeeper Paul Robinson to thank for not being further behind at the break.
Eventually Robinson was unable to prevent greater damage when he turned Eagles' 61st-minute free-kick against the post to leave Lee with a close-range formality, before Jordan Rhodes headed Rovers to within touching distance of a scarcely deserved point eight minute from time.
Victory ended a run of four straight draws for Bolton, still unbeaten in six games under Freedman's stewardship, while Blackburn must bounce back from consecutive defeats and a stuttering start to Henning Berg's tenure when they make the short trip to face fierce rivals Burnley on Sunday.
- Sports & Recreation
- Kevin Davies
- Jacob Butterfield
- Dougie Freedman