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Charles Oliveira will face Islam Makhachev for the lightweight title in the headline event of UFC 280 in Abu Dhabi.
Oliveira has long been viewed as the defending lightweight champion, though the fight will be for the vacant 155-pound belt at the Etihad Arena on October 22.
The Brazilian secured the title last year after knocking out Michael Chandler before defending his title against Dustin Poirier in December.
But Oliveira surrendered his belt after he failed to make the weight for his next defence in May against Justin Gaethje, who he then defeated by submission in a non-title fight at UFC 274.
Retired former champion Khabib Nurmagomedov will be backing team-mate and long-time friend Makhachev in the United Arab Emirates, with the former winning his last 10 UFC fights in a row.
Oliveira has also triumphed in his last 11 consecutive bouts, including 10 finishes, setting up a highly anticipated fight between two of the most talented fighters in the world at present.
Yet Oliveira will pose the toughest task Makhachev has faced in UFC, given Dan Hooker and Arman Tsarukyan are the only two top-15 lightweight fighters the Russian has defeated in his 11 UFC wins.