Leaders Chelsea could effectively knock Manchester City out of thePremier League title race on Wednesdaywith an eleven-point gap already in place between the two sides.
However, Antonio Conte's men are now only seven points clear at the top of the table, with second-placed Tottenham having taken full advantage of last weekend's shock 2-1 defeat at home to Crystal Palace.
Chelsea, though, secured a 3-1 win over City at the Etihad in December and they will be favourites to complete a home-and-away double over a side that has won just one of their last five matches against the league's top seven teams.
Victor Moses is a major doubt to face City after missing the game against Palace. The wing-back is still suffering from the calf injury that forced him off against Stoke City three weeks ago.
Eden Hazard, Thibaut Courtois, Diego Costa and John Terry were all available at the weekend despite recent injury concerns.
However, Courtois is believed to be receiving ongoing treatment for fluid accumulation in his hip, while Cesar Azpilicueta is also playing on despite a broken bone in his hand.
David Luiz is also carrying a minor knee injury that he suffered as a result of the tackle that saw Sergio Aguero sent off in Chelsea's win over City in December.
Chelsea have no players suspended for the match and have had few issues with discipline all season. John Terry has been their only player to besent off, in the FA Cup against Peterborough United.
In 2017, the rules altered slightly regarding suspensions for an accumulation of yellow cards, with 10 bookings now being required to activate a ban. Diego Costa and David Luiz are two bookings away from a two-match suspension as they are now oneight for the campaign.
The 10-bookings rule would lead to a two-match suspension, but they are "reset" after the second Sunday in April.
CHELSEA POTENTIAL STARTING LINE-UP
Conte came up with a surprise formation as he opted for a 3-5-2 against Palace on Saturday. The change in system was to deal with the loss of Moses through injury but Conte switched back to his preferred 3-4-3 in the second half.
For once, it is hard to guess what system Conte might employ against Manchester City, with his most recent tactical tweak impacting upon his team's fluidity. Conte may opt to use Willian in Moses' role, as he did off the bench on Saturday, but it is still unconfirmed whether Moses will return on Wednesday.
The rest of his line-up is likely to remain more or less the same, butNemanja Matic and Cesc Fabregas will again compete for a spot incentral midfield. Given the attacking quality of the opposition, the more defensively minded Serbian might get the nod this time around.
Elsewhere, Diego Costa will lead the line, but he has been misfiring of late, undermining his hopes of beating Tottenham's Harry Kane and Everton's Romelu Lukaku in the race for this season's Premier League Golden Boot.
MANCHESTER CITY TEAM NEWS
Jesus Navas played at right-back against Arsenal on Sunday, as Man City had injuries to bothPablo Zabaleta and Bacary Sagna. Zabaleta, though, may return against Chelsea after coming off the bench late on in the match at the Emirates Stadium.
Gabriel Jesus is off his crutches but he remains unavailable for selection, whileIlkay Gundogan is continuing his recovery from a season-ending cruciate ligament injury.
Vincent Kompany is available to face Chelsea but he will likely remain on the bench after a long spell of injury problems.
Guardiola has insisted that Raheem Sterling has got over his own fitness issues and he is likely to start despite being taken off at half-time against Arsenal, a decision his manager said was purely tactical.
BEST OPTA MATCH FACTS
Chelsea haven’t lost back-to-back home league games against Man City since December 1983.
Pep Guardiola has never previously lost both league games against a single opponent in the same season in his coaching career so far.
Sergio Aguero scored a hat-trick in this exact fixture last season as City won 3-0 – one of just three opposing players to hit a treble in a Premier League game at Stamford Bridge (Kanu in October 1999 and Robin van Persie in October 2011).
TV COVERAGE & KICK-OFF TIME
The game is being shown at 20:00BST on BT Sport 1 in the United Kingdom on Wednesday evening.