When and where is the match?
It's on Wednesday, April 5, at Stamford Bridge.
What time is kick-off?
While most of Wednesday night's games are 7.45pm, Chelsea v Man City is one of two that kicks off at 8pm.
What TV channel is it on?
BT Sport 1 from 7.15pm.
What is the team news?
Victor Moses is an injury doubt. The right wing-back missed Saturday's loss to Crystal Palace with a toe injury and is one of "two or three situations" to be monitored before the City match.
Eden Hazard played against Palace following a calf injury which saw him miss international duty with Belgium, while David Luiz is still managing a knee injury sustained against City in December.
Provisional squad: Courtois, Begovic, Fabregas, Zouma, Alonso, Kante, Hazard, Loftus-Cheek, Moses, Pedro, Costa, Matic, Willian, Batshuayi, Cahill, Terry, Azpilicueta, Chalobah, Luiz, Eduardo, Aina, Ake.
Any further news?
Gabriel Jesus has returned to training with City seven weeks after breaking a bone in his foot.
The Brazil striker underwent surgery after fracturing a metatarsal in City's Premier League victory at Bournemouth in February.
Manager Pep Guardiola said last week Jesus - who turned 20 on Monday - was ready to resume some form of training and the club have now confirmed he has done some "light ball work".
Jesus's progress raises hopes he could return to action before the end of the season. It was initially feared he may not play again this term.
A report on the club's website confirmed the player "stepped up his recovery from injury today when he returned to the training field for the first time since February".
Jesus made a big impact after joining the club from Palmeiras in January, scoring three goals in five appearances and displacing Sergio Aguero from the side.
Chelsea v Man City in numbers
4 - Red cards in the last five league fixtures between the two clubs - including the fixture at the Etihad Stadium earlier this season, when Fernandinho and Sergio Aguero were both shown red in stoppage time.
16 - Goals in the last four meetings in all competitions, with both teams winning two games each.
2013-14 - The last time Chelsea did the league double over City.
7 - Sergio Aguero has scored seven goals against Chelsea, with six of those coming in his last seven appearances against the London side - including his hat-trick last season at Stamford Bridge. He is one goal away from matching the haul of Frank Lampard, who scored seven in the fixture for Chelsea before netting an 85th-minute equaliser against his former club in 2014 for City.
6 - Even after losing to Crystal Palace, Chelsea have only dropped six points at Stamford Bridge all season, their other defeat coming back in September when they lost 2-1 to Liverpool.
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10 - The number of goals Chelsea have conceded at Stamford Bridge in the league so far this season. City, though, have scored 10 goals in their last four away league games.
2014-15 - The last time there was a draw in the fixture. Both games that season ended in 1-1 draws, two of only seven in the 39 Premier League meetings between the clubs.
116 - Goals scored between the two teams in the Premier League so far this season. Chelsea just edge it with 60 goals, compared to City's 56.
Premier League standings
What are they saying?
Chelsea striker Diego Costa
"Now is not the time to let ourselves down. We should keep our heads up and think ahead for the next game since it will be very important.
"This game against City will be a six-point affair since if we win... they will (effectively) be out of the title race while we keep the advantage."
Chelsea manager Antonio Conte
"It's normal with 27 points available that anything can happen in the league. We need 21 points to win the league mathematically. I think we are in a really good position.
"Nobody thought that Chelsea could fight this season for the title, but we stay there. We stay there and we want to keep this position.
"We know there are many teams that want to win the league, but it's normal this. I hope that who wins this league will deserve to win the league."
What are the best odds?
Chelsea to win 7/5
Manchester City to win 21/10
What is our prediction?
From seemingly strolling towards the title Chelsea suddenly face a major test of their credentials. Saturday's shock home defeat by Crystal Palace, and Tottenham's win at Burnley, cut the Blues' lead from 10 points to seven.
Seven points is still a pretty healthy advantage in anyone's book, but City are capable of defeating anybody on their day, even Chelsea, and if that happens their lead could be shrunk even further if Tottenham defeat Swansea away on the same night. As things stand, this match looks too close to call.
Predicted score: Chelsea 2 Man City 2