Chelsea booked their place in the FA Cup final by beating Tottenham at Wembley on Saturday and are now looking to tie up the Premier League title.
Eden Hazard's superb cameo off the bench inspired the Blues to a 4-2 victory over their rivals and they now return to Stamford Bridge looking to deal them another blow by staying on track for the league championship.
Standing in their way are Southampton, who are well rested having not played at the weekend amid the cup fixtures.
Chelsea vs Southampton
Tuesday, April 25, 2017
19:45 GMT, 14:45 ET
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via Sky Go.
UK TV channel
Sky Sports 1
In the US, the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
US TV channel
NBC Sports Live
SQUADS & TEAM NEWS
Begovic, Courtois, Eduardo
Zouma, Cahill, Terry, Azpilicueta, Aina, Alonso, Luiz, Ake
Fabregas, Hazard, Matic, Willian, Loftus-Cheek, Moses, Kante, Chalobah, Kenedy
Pedro, Costa, Batshuayi, Solanke
Gary Cahill missed the FA Cup semi-final against Tottenham due to illness and could be a doubt once again, though Nathan Ake's impressive performance in that match is a boost in that regard.
Eden Hazard and Diego Costa are expected to come back into the starting XI, with Willian battling Pedro for the other spot in Chelsea's forward line.
Cedric, Yoshida, Gardos, Martina, Pied, Stephens, Bertrand, Caceres
Clasie, Davis, Tadic, Romeu, Ward-Prowse, Reed, Redmond, Hojbjerg, Boufal, Isgrove, Hesketh, McQueen, Sims
Long, Rodriguez, Austin, Gabbiadini
Southampton have Oriol Romeu back after suspension but Alex McCarthy, Virgil van Dijk and Matt Targett remain out. Charlie Austin is nearing a return but his precise status is currently unknown.
Potential starting XI: Forster; Cedric, Yoshida, Stephens, Bertrand; Ward-Prowse, Clasie, Hojbjerg; Tadic, Gabbiadini, Redmond.
BETTING & GAME ODDS
Chelsea are 4/9 favourites to win at home, according to Oddschecker, with Southampton priced at 15/2 and the draw available at 4/1.
Diego Costa is the 31/10 favourite to score first, with Eden Hazard and Michy Batshuayi next at 17/4. Manolo Gabbiadini is the top choice for the Saints at 9/1.
There were no points up for grabs, but Chelsea's victory over Tottenham felt like a major statement in the Premier League title race as well as in the FA Cup.
The Blues sent a message to their nearest title rivals having slipped up on a couple of occasions over the past few weeks, and may have discovered another player to add to the small core Antonio Conte relies upon in the process.
Nathan Ake excelled alongside David Luiz and Cesar Azpilicueta as Gary Cahill's replacement, and it would not be a surprise to see the young Dutchman convince Conte to make that switch a permanent one next season.
Michy Batshuayi, on the other hand, may still have work to do to convince the Italian he has a future at Stamford Bridge, but the gamble of resting Eden Hazard and Diego Costa paid off handsomely.
Hazard won the game for Chelsea while registering just over 30 minutes on the pitch and the little bit of extra rest he enjoyed could prove valuable ahead of another difficult week of league fixtures.
With Costa continuing to look out of sorts, Hazard may need to be the hero a few more times this season to drag Conte's men over the line.