Bucharest Wolves completed the double over Crociati with a 13-26 victory at the Stadio XXV Aprile.
A brace of tries from Florin Surugiu set the visitors on their way to the lead in the first half, and only two tries in the final 10 minutes rescued any dignity for the hosts.
Redford Pennycook scored for Newcastle Falcons but it was not enough to prevent a 21-13 Amlin Cup defeat to Lyon Olympique.
The openside claimed his first try of the season, following an impressive break from Mark Wilson, to cancel out Mosese Ratuvou's early score.
Jimmy Gopperth slotted the conversion and then kicked the Falcons 13-7 ahead with a brace of penalties either side of half-time.
However they failed to press home their advantage at Matmut Stadium, where Lyon responded with a penalty try converted by Romain Loursac before replacement Laurent Tranier stepped off the bench to cross for the home team's third try.
Jonny Wilkinson guided Toulon to a home draw in the quarter-finals with a comfortable 50-6 victory in Italian over minnows Petrarca.
The fly-half converted six of the seven tries the rampant visitors ran in, as well as notching a first-minute penalty to settle Toulon into the game.
With Newcastle beaten in Lyon, the result assured Toulon of top spot in Pool One.
Exeter Chiefs claimed a historic 31-14 Amlin Challenge Cup victory over European giants Perpignan to claim their first appearance in a European quarter-final in style.
The Chiefs looked destined for a heavy loss as the French club surged into a 14-0 lead within 10 minutes of kick-off but turned the game around thanks to the boot of Ignacio Mieres and a Hayden Thomas try.
Brett Sturgess and James Phillips then grabbed second-half touchdowns to seal the win and qualification to the knockout stages.
But Exeter will have to wait until Wasps' clash with Bordeaux-Begles on Sunday to learn if they have done enough for a home quarter-final.
The Catalan giants came flying out of the blocks at Sandy Park with quickfire tries from Charles Geli and Jeffrey Michel, both converted by James Hook.
Mieres hit back with the boot before Thomas burrowed over following a driving lineout.
Sturgess raced clear to score on the hour before Phillips wrapped up the win, cutting through after Gareth Steenson's penalty rebounded off the post.
Newport Gwent Dragons ended their campaign with a convincing 45-16 win over Cavalieri Prato.
Rhys Buckley, Adam Hughes, Aled Brew, Andy Tuilagi, Jason Tovey, Martyn Thomas and Lewis Roblin all scored.
Worcester suffered their heaviest defeat in Europe for seven years, a 33-10 reverse at Stade Francais, to end any hope of progressing in the Amlin Challenge Cup.
The Warriors had the chance to qualify for the quarter-finals but were over-powered by a star-studded Stade team.
Paul Warwick, Sergio Parisse and Morgan Turinui set the star-studded Parisians on course for top spot in Pool One.
Andy Goode struck back for Worcester in the second half with a solo score but former England wing Paul Sackey and ex-All Black Byron Kelleher completed the demolition late on at Stade Charlety.
Goode handed Worcester an ideal start with a fifth-minute penalty but Stade hit-back within two minutes as Warwick finished a break by Julien Dupuy.
Italian captain Parisse then followed before Wallaby Turinui claimed a third try, all converted by Jules Plisson, for a 21-3 lead at half-time.
Goode claimed a solo score in the 50th minute but Sackey and Kelleher saw Stade claim the top ranking for the quarter-finals.