Comolli, who had previously held a similar role at Tottenham Hotspur, spent more than £100 million on players since taking the role at Anfield in November 2010.
Those acquisitions included star striker Luis Suarez, but the purchases of players such as Andy Carroll – for a club record £35 million – Jordan Henderson and Stewart Downing have drawn criticism.
Here are all 11 signings that Liverpool made under Comolli's watch.
In his first 16 months in England the Uruguayan striker has been embroiled in more controversy than many players are in their entire career. Despite that, Suarez is one of the most threatening attacking players in the Premier League, giving even the best defenders nightmares.
The cost of signing the striker from Newcastle – who was injured at the time - was largely offset by the £50m fee received on the same day for Fernando Torres's move to Chelsea, but he still has a long way to go before he is regarded as anything other than one of the biggest wastes of money ever in the English game.
Perhaps the most surprising of all of Comolli's signings, given he was just 20 at the time and the fee involved. Henderson has not come close to justifying Liverpool's considerable investment in him thus far. Just one goal and one assist in the league so far despite seeing a surprising amount of minutes on the pitch.
As Blackpool's captain last season, Adam was the midfield maestro who took every set piece, scored and set up goals with regularity. At Liverpool, he has come to a club where that role is well and truly Steven Gerrard's, and has struggled to adapt accordingly. Just six league assists for the Scotsman this season.
No other player has taken more shots on goal in the Premier League this season without scoring than Downing's 62. That statistic would perhaps be forgiven if he had been laying them on for his new team-mates, but he has not registered an assist in the league for Liverpool yet either.
The Brazilian goalkeeper was famously between the sticks when Manchester United put seven past Roma in the Champions League five years ago. Conceded within 10 minutes of his debut against Aston Villa, while in his second match against Blackburn on Tuesday he was sent off.
Arguably the shrewdest signing by Liverpool under Comolli's stewardship, the Spanish left-back has proved good value at left-back for his surprisingly low fee. Certainly an upgrade on Paul Konchesky.
The young Uruguayan scored one of the goals of the season with his acrobatic overhead kick in the recent defeat at QPR, but few would disagree that he is still very much a work in progress.
By far the best value signing of this crop. Liverpool took full advantage of Manchester City's decision to cast off the Welshman by sealing his return to Anfield on a free. The Welshman has already matched the total of nine goals scored in his previous season at the club five years ago, and in more than a dozen fewer games too.
Liverpool beat off competition from Manchester United and Tottenham to sign the Wycombe wunderkid, who became the Football League's youngest goal scorer last October when he scored against Sheffield Wednesday 10 days shy of his 16th birthday.
The 18-year-old goalkeeper signed from Wrexham towards the end of the January window. The way Liverpool are losing goalkeepers at the moment, he may see first-team action before the end of the season.