Atletico Mineiro claimed a big win to close in on the Copa Libertadores knockout stages, while Flamengo bounced back.
Mineiro climbed to the top of Group 6 courtesy of a 5-1 thrashing of Sport Boys in Bolivia on Wednesday.
Juan Cazares opened the scoring after a defensive error before Rafael Moura struck in the 17th minute with a sublime finish into the top corner.
A Jose Castillo penalty before half-time gave the hosts hope, but that disappeared thanks to Elias and Romulo Otero, the latter the beneficiary of a goalkeeping howler.
Cazares sealed his brace to complete the result, which has Roger Machado's Mineiro (10 points) and Godoy Cruz (10) clear of Libertad (4) and Sport Boys (1).
Group 4 is far more delicately poised as Flamengo and San Lorenzo claimed wins.
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Flamengo are two points clear at the top after late goals from Paolo Guerrero and Miguel Trauco saw them past Universidad Catolica 3-1 in Rio de Janeiro.
Santiago Silva had cancelled out Rodinei's opener in the second half, but Flamengo responded late on.
Flamengo (9 points) are ahead of San Lorenzo (7), who recorded a comfortable 3-0 win at Atletico Paranaense.
Atletico (7) points sit third, while Universidad Catolica (5) are bottom.
Group 5 leaders Palmeiras suffered their first loss by going down 3-2 to Wilstermann, while Deportes Iquique claimed a third straight win in Group 8 by overcoming Gremio 2-1.