For the first time since 2018, Farrell has been overlooked as skipper with Eddie Jones opting for Lawes after the Northampton flanker impressed in the role while deputising in the autumn and Six Nations.
The Saracens playmaker has made a full recovery from the ankle injuries that have disrupted his season and features in the midfield, lining up between fly-half Marcus Smith and outside centre Joe Marchant.
Joe Cokanasiga provides tackle-busting power on the left wing in his first Test for a year having overcome a series of setbacks, including injury and Covid.
London Irish’s teenage sensation Henry Arundell could make his debut as a replacement at Optus Stadium as his stellar first season as a professional continues its upwards trajectory.
Joining van Poortvliet among the substitutes is his Leicester team-mate Leicester, who is the third uncapped player named in the 23.
Charlie Ewels has become the first player to be ruled out of the tour after suffering a knee injury in training on Wednesday and his place is being taken by Bristol’s Sam Jeffries.