Pattinson was diagnosed with a stress fracture of his lower back following Sunday's conclusion to the second Test defeat at Lord's and will return home to Australia after the third Test at Old Trafford.
Team doctor Peter Brukner said: "James Pattinson reported some hip and back soreness on the final day of the second Ashes Test.
"We had some scans done today in London that have identified an early stage low back stress fracture. Unfortunately he will not take any further part in this Test series and will commence a rehabilitation program with the aim to have him back for the Australian summer."
No replacement for Pattinson has been called up ahead of this week's warm-up game against Sussex, though the likes of Josh Hazlewood, Nathan Coulter-Nile and the in-form Chadd Sayers could, if required, be called up from the Australia A squad currently playing in South Africa.
Before that option is considered, the selectors could opt to recall Mitchell Starc after he was left out for the 347-run hammering at Lord's, while James Faulkner and Jackson Bird are also available to back up Peter Siddle and Ryan Harris.
Cricket Australia general manager Pat Howard said: "While we are obviously disappointed for James, the selectors have five bowlers fit and ready to perform in England, providing them with many options.
"It is also important to note that several players have been performing for Australia A and are available to be called up at any stage if the NSP required them.
"We've been well planned to have as many bowlers fit and available in the lead-up to this important series and while this setback for James is disappointing, we are confident we have good fast bowling depth."
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- James Pattinson
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