The game was scheduled for a 3pm BST kick-off time on Saturday September 17 at Brighton’s Amex Stadium but planned industrial action on the rail network has seen it delayed.
A new date for the rescheduled match will be announced in due course.
A Palace statement read: “Following a request to the Premier League Board by Brighton and Hove Albion F.C, the club’s home fixture against Crystal Palace F.C, due to be played at 15:00 BST on Saturday, 17th September, has been regrettably postponed.
“The decision follows exceptional circumstances relating to the planned industrial action on the rail network, with authorities unable to sanction the fixture to be played with no public transport available for supporters.
“The Premier League has consulted with both clubs, police, the SAG for Brighton & Hove City Council and other relevant authorities in exploring alternative plans but all have agreed there was no other option but to postpone the fixture.”