Jeffrey Schlupp and Jean-Philippe Mateta come in to the team with Conor Gallagher also absent from Patrick Vieira’s squad.
Vicente Guaita, Luka Milivojevic, Eberechi Eze, Christian Benteke, Michael Olise and Nathaniel Clyne were all missing against Tottenham.
Goalkeeper Guaita returns to the XI with only Benteke and Milivojevic on the bench.
Before he leaves for the Africa Cup of Nations, Jordan Ayew is still in the XI and there is even more onus on him, Mateta and Odsonne Edouard to deliver in Zaha and Gallagher’s absence.
Crystal Palace XI: Guaita,; Ward, Andersen, Guehi, Mitchell; Hughes, Kouyate, Schlupp; Ayew, Mateta, Edouard.
Subs: Butland, Matthews, Tomkins, Kelly, Ferguson, Milivojevic, Riedewald, Benteke.
Date and kick-off time: 3pm, Tuesday December 28, 2021.
Venue: Selhurst Park, London
TV channel: Amazon Prime