With no GC contenders in the breakaway, the group were allowed to lead from start to finish as the favourites saved themselves for Sunday’s final stage.
Clement was joined by Pieter Serry, Damien Howson, Pierre Rolland, Jens Voigt, Antonio Piedra, Marek Rutkiewicz, Rudy Molard and Nico Sijmens at the front, with the group quickly amassing a sizable lead.
With the peloton reluctant to expand energy, it was left to the nine riders at the front to jostle for victory - each solo attack thwarted until Clement finally broke clear and held on for victory.
"I thought it was all lost because I had to gamble and I tried to take back the guys who had attacked and spent some energy there," said Clement.
"At one point there were four guys gone [up the road], and I thought ‘ok, somebody has to bring this back' and if they didn't then I would have lost.”
Joaquin Rodriquez maintained his four-second lead over Alberto Contador in the overall standings, with Tejay van Garderen three seconds further adrift in third.
Britain's Chris Froome is sixth, 17 seconds off the pace.
Stage six results
1. Stef Clement (Netherlands / Belkin) 3:58:44"
2. Rudy Molard (France / Cofidis) +3"
3. Pieter Serry (Belgium / Omega Pharma - Quick-Step)
4. Jens Voigt (Germany / Trek)
5. Marek Rutkiewicz (Poland / CCC)
6. Antonio Piedra (Spain / Caja Rural)
7. Pierre Rolland (France / Europcar)
8. Damien Howson (Australia / Orica)
9. Nico Sijmens (Belgium / Wanty) +9"
10. Tosh Van der Sande (Belgium / Lotto) +55"
1. Joaquim Rodriguez (Spain / Katusha) 27:03:13"
2. Alberto Contador (Spain / Tinkoff - Saxo) +4"
3. Tejay van Garderen (U.S. / BMC Racing) +7"
4. Romain Bardet (France / AG2R) +10"
5. Nairo Quintana (Colombia / Movistar)
6. Chris Froome (Britain / Team Sky) +17"
7. Andrew Talansky (U.S. / Garmin) +18"
8. Domenico Pozzovivo (Italy / AG2R) +26"
9. Warren Barguil (France / Giant) +42"
10. Robert Kiserlovski (Croatia / Trek) +48"
- Sports & Recreation
- Pieter Serry
- Pierre Rolland
- Antonio Piedra
- Jens Voigt
- Stef Clement
- Marek Rutkiewicz
- Rudy Molard
- Nico Sijmens
- Alberto Contador