Vandborg, who rode alongside Basso for Liquigas in 2009, returns to the World Tour after a year on the Professional Continental circuit with Canadian team Spidertech.
The 30-year-old began his career with Team CSC in 2004 before stints with Discovery Channel, Team GLS then Liquigas.
He left the Italian team in 2011 for Saxo Bank-Sunguard, where he helped Alberto Contador win the Tour de France - a title the Spaniard has since been stripped of - before dropping out of the top flight to sign with Spidertech last season.
"We parted on good terms at the time, and I was really happy to ride for them. They have a great set-up, and I know that things are working well. So I am very pleased to again be a part of it," Vandborg told TV2 Sporten.
"They [Liquigas] respected that I wanted to try riding for Bjarne Riis then. Many of my Danish friends raced there, and the team had Alberto Contador. This meant that I could work for victory in the Tour de France."
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