At the conclusion of the 207km stage, Blanco's Dutch rider Boom edged ahead of Frenchman Vichot (FDJ), with Italian Daniel Oss (BMC) and Boom's compatriot and team-mate Laurens ten Dam just behind.
Norway's Thor Hushovd (BMC), who impressed with a comeback victory in stage one on Saturday, was 14 seconds off the pace in sixth and 10s behind France's Pierrick Fedrigo (FDJ).
Hushovd ends the French mini-tour in fifth, with Boom and Ten Dam sharing winner Vichot's overall time.
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- Thor Hushovd