Yvan Watremez and Brice Dulin are both set to make their debuts on Saturday when France face Argentina in Cordoba, coach Philippe Saint-Andre has announced.
Biarritz lock Watremez, 23, and Castres back Dulin - a year younger at 22 - will join the likes of experienced quartet Dimitri Szarzewski - capped 61 times - Pascal Pape, Morgan Parra and Francois Trinh-Duc.
Saint-Andre announced the team in Buenos Aires on Thursday morning for the first of two Tests against the Pumas, moving Jean Marcellin Buttin to the wing to allow for Brice's inclusion. Saint-Andre said: "Brice showed us that he is sparkling, he does well in the group."
He added: "He has the responsibility to be the cleanest and most consistent as possible.
"(With) Jean Marcellin, they are two good players with the high balls."
Yoann Huget is back in the fold after a spell where his career went backwards culminating in a four-month ban just before last autumn's World Cup in New Zealand for three missed drugs tests. Fulgence Ouedraogo also returns.
Of Wesley Fofana, a revelation in the Six Nations, Saint-Andre added: "During training he was impressive in his speed, responsiveness and punch.
"This will make the pairing with Florian Fritz very interesting."