EFL Cup fourth round draw: United to face City, Liverpool at home to Spurs
Pep Guardiola will travel to Old Trafford again as his side will take on Jose Mourinho's Reds in the last 16
Manchester will have another derby in he EFL Cup.
The Reds and the Blues were drawn against each other in the last 16 in the biggest tie of the round.
Two weeks ago, City won 2-1 at United in the League.
Elsewhere, Premier League big hitters Liverpool are at home to Tottenham, the sides having already drawn 1-1 at White Hart Lane this season.
West Ham - who struggled past Accrington Stanley in round three - have been drawn at home to Chelsea, having suffered a 2-1 Premier League defeat to the Blues at Stamford Bridge earlier this season.
Arsenal are at home to Championship Reading.
DRAW IN FULL
Southampton v Sunderland
Newcastle v Preston
Leeds v Norwich
Bristol City v Hull
Liverpool v Tottenham
Arsenal v Reading
Manchester United v Manchester City
West Ham v Chelsea