Embiid tripped over teammate Georges Niang with 5:53 remaining in the fourth quarter of Saturday's loss to the Minnesota Timberwolves, writhing in pain on the ground before being attended to by a trainer and hobbling to the bench at Wells Fargo Center.
The Sixers confirmed on Monday that the Cameroonian superstar has sustained a left midfoot sprain, meaning he will be absent for Tuesday's clash with the Brooklyn Nets and Wednesday's trip to the Charlotte Hornets.
Embiid has been in imperious form of late, averaging 32.3 points per game for the season and recently scoring 59 against the Utah Jazz.
That was 56.2 per cent of the Sixers's total of 105, the highest percentage of a team's points in an NBA game played in the state of Pennsylvania since Wilt Chamberlain's 100-point game in Hershey in March 1962 (59.2 per cent).
The 28-year-old joins James Harden and Tyrese Maxey in the treatment room, with the duo also sidelined with foot issues.
It leaves Tobias Harris as the only available member of the Philadelphia roster averaging double figures for points per game this season, though he only returned to training on Monday after missing the last two games with a hip issue.