The prospect of playing the fixtures with “hardly any or no spectators at all was not a viable option” for Dutch cricket, according to a joint statement from the two boards.
The matches are part of the ICC’s ODI Super League.
“The participation of The Netherlands in the ICC competition, as the only Associate Member, is an enormous challenge for Dutch cricket, and the home matches versus England would be a great chance to put cricket on the map in the country,” read the statement.
England managing director Ashley Giles said the news was “disappointing”.
“Hopefully, with the prospect of crowds returning to sport soon, we can rearrange the three matches in 2022 and showcase international cricket to capacity crowds,” he said.
“I am sure many fans will want to travel across from England and be part of this historic ODI series.”
England begin their winter programme on Friday afternoon with the first of three T20s in South Africa.