It hasn’t been a campaign that either team will look back on with much fondness, with Die Mannschaft so far winning just one of their five games and the Three Lions faring even worse - not a single victory and relegation already assured.
Both Gareth Southgate and Hansi Flick will feel they have big issues to sort out, despite words said in public of late, before they head to the 2022 World Cup in November.
Players on both sides will also be hoping to get a chance to prove they can make the difference, perhaps earning a starting spot in Qatar as a result.
Here’s everything you need to know ahead of the match.
When is England vs Germany?
England face Germany at Wembley on Monday 26 September, with kick-off scheduled for 7:45pm BST.
Where can I watch it?
The Three Lions’ Uefa Nations League games are now broadcast on Channel 4. The game can also be streamed via the All 4 app and desktop platforms, using all devices including smart TVs.
England XI: Pope, James, Stones, Dier, Maguire, Shaw, Bellingham, Rice, Foden, Kane, Sterling
Germany XI: Ter Stegen, Hofmann, Sule, Kehrer, Raum, Kimmich, Gundogan, Musiala, Schlotterbeck, Sane, Havertz
A dismal run to end in dismal style. Germany are nowhere near their finest version either and this could be a tough watch. England 1-1 Germany.