While Harry Kane’s penalty away in Germany on Tuesday rescued a point for Gareth Southgate’s side, the Three Lions sit bottom of Group A3 and need a victory to raise morale.
Indeed, it was Italy who caused England the ultimate heartbreak in the Euro 2020 final, and beating them at Molineux - albeit behind closed doors - would be a big scalp after two fairly disappointing games thus far.
If England can get three points from the table-toppers, they can move to end this summer on a high with the World Cup in Qatar looming.
Here’s everything you need to know about where to watch tonight’s game...
Where to watch England vs Italy
TV channel: Tonight’s game will be televised live on terrestrial television for free via Channel 4, with coverage beginning at 7pm.
Live stream: All 4 will also show the match live on its website.
Live blog: You can follow all the action via Standard Sport’s live blog, with Simon Collings and Malik Ouzia providing expert analysis from Molineux.