The Gunners are without Shkodran Mustafi, who is suffering from a thigh injury, so it is a back three of Gabriel, Laurent Koscielny and Rob Holding.
Olivier Giroud starts up front for Arsenal, with Alexis Sanchez and Mesut Ozil in behind.
Pep Guardiola names an attacking side with Sergio Aguero supported by Kevin de Bruyne, David Silva and Leroy Sane.
City are without John Stones so it is Vincent Kompany and Nicolas Otamendi in the centre of defence.
Read the full article on eurosport.co.uk: Arsenal stick with back three, Aguero leads City line