Olympique Lyon clung on to eliminate AS Roma 5-4 on aggregate despite a 2-1 defeat, while former European trophy winners Ajax Amsterdam and Anderlecht also went through.
Russia's interest in this season's European competitions ended as Krasnodar threw away a promising position at home to Celta and lost 2-0 for a 4-1 aggregate defeat.
Besiktas hammered Olympiakos 4-1 (5-2 on aggregate) despite having Vincent Aboubakar, scorer of their first goal, sent off six minutes before halftime.
Genk eliminated fellow Belgians Gent 6-3 on aggregate after a 1-1 draw.
Juan Mata's second-half goal gave the English Premier League's only survivors in the competition a 2-1 aggregate win.
RESULTS FROM THE UEFA EUROPA LEAGUE LAST 16 SECOND LEG MATCHES
Besiktas 4 - 1 Olympiacos - Besiktas win 5-2 on aggregate
Read the full article on eurosport.co.uk: Schalke recover to reach Europa League last eight, Lyon eliminate AS Roma