Kante has become one of the most influential midfielders in the division, playing a huge role in Leicester's memorable title win last season and looking good for a second successive championship, this time with Antonio Conte's Chelsea.
Romeu, on the other hand, is now one of Saints' most influential players, performing in the defensive midfield anchorman role admirably following Victor Wanyama's summer departure to Tottenham.
The 25-year-old Spaniard came through the ranks at Barcelona before moving to Stamford Bridge in 2011. He was on the Chelsea books for four years but spent time on loan with Valencia and Stuttgart.
Ahead of Southampton's trip to west London, Puel has compared Romeu, who is expected to start against his former club after missing Saints' last two games through suspension, to Kante and the manager feels both men are almost equals in terms of quality.
"I think he's not far off Kante," Puel said at his pre-match press conference. " He is very important for us. He recovers the ball so well and is a technical player.
"If we see the quality of his games since the beginning of the season, N'Golo Kante brings the same qualities as Oriol for us because he's very consistent and in every game he gives good performances, with consistency and quality.
"He's an important player for this team because he can do fantastic work to recover the ball and start the play.
"Without (Kante) for Chelsea it's difficult and the same with Romeu, it's difficult for us without him.
Read the full article on eurosport.co.uk: Claude Puel: Oriol Romeu is almost as good as N'Golo Kante