Spurs head into the clash at Wembley buoyed after a weekend in which they hammered Bournemouth 4-0 before Chelsea were beaten 2-0 by Jose Mourinho's Manchester United.
Chelsea sat 10 points clear at the top of the table just over a fortnight ago, but two defeats, the first against Crystal Palace, in four matches have thrust Tottenham back into contention.
Both sides will now turn their attention to next weekend's FA Cup showdown in which Kane says Spurs can not only book their place in the final, but also sow further seeds of doubt in the Chelsea squad.
"It could be a big thing psychologically," Kane said.
"Of course it's a different competition so it's hard to say, but it's a big game for us, a big game for the club, a massive semi-final and you never know.
If we win next week it might put a bit more doubt in their minds regarding the Premier League. But we can't control what Chelsea do.
Tottenham are certainly the form team going into the clash, having won eight matches in a row in all competitions and scored an average of three goals a game in that period.
They already have 71 points, one more than last year's final total, with six matches still left to play and are one short of their Premier League record tally of 72 points, set under Andre Villas-Boas in 2013.
Read the full article on eurosport.co.uk: Harry Kane: ‘FA Cup win over Chelsea would leave them doubting title’