Klopp has warned his squad they cannot afford to be passive at the Etihad Stadium or they risk being bypassed by City's ball players and so the plan is likely to be to go on the attack.
Monaco did it for 45 minutes in the south of France in midweek to wipe out a two-goal deficit but found themselves under pressure after the break and only a late goal which levelled the aggregate score at 6-6 allowed them to progress on away goals.
Guardiola and his players were criticised for squandering a two-goal advantage from the first leg and with fourth-placed Liverpool only a point behind going into this weekend's clash the pressure is on to bounce back.
"I am not in doubt about his quality. Maybe a few people are but I am not. I respect him a lot," said Klopp.
"I know probably a few people think (differently) now they are out of the Champions League but I think the way they played was quite impressive as Monaco.
"City could have won the game easily in the second half but because they are human beings they missed a few chances.
"For me City is the most difficult team to play. I know their image at this moment in this country is a little bit different.
"I've heard about Pep Guardiola's style and all that stuff but it is real football and it is difficult to defend against them and a lot of teams have failed already.
"If you are passive against City you have no chance. You have to be active and to be active you need to be brave.
Read the full article on eurosport.co.uk: Jurgen Klopp rates Manchester City as 'most difficult team to play'