Forward Germain scored twice in the first half as Monaco overwhelmed a Lille side who were reduced to 10 men after defender Carlens Arcus was sent off five minutes before the interval.
Monaco looked nothing like the side who were beaten 4-1 in the League Cup final by Paris St Germain on Saturday as they joined En Avant Guingamp, 1-0 winners at fourth division Frejus-St Raphael, in the last four.
Germain opened the scoring in the 35th minute with a missile into the roof of the net from just outside of the box after eluding two defenders.
Arcus was shown a straight red card for fouling Jorge, who was charging towards the box after being set up by Nabil Dirar.
Germain doubled the lead on the stroke of halftime with a fine volley from Irvin Cardona's cross from the right.
Read the full article on eurosport.co.uk: Monaco down Lille to reach French Cup semis