The Rojiblancos lie fourth in the standings, five points behind Sunday's opponents and 10 adrift of leaders Real Madrid, prompting suggestions that defeat will signal the end of their top-three challenge once and for all.
Simeone acknowledges Jorge Sampaoli's Sevilla are the form team at present, as they defend a seven-match unbeaten run in LaLiga, but is adamant Atletico's season does not hinge on one result.
"What is clear is that we are facing a team who have been very consistent, especially in the league, and who are fighting for the top spots." the Argentinian said in quotes reported by Marca.
"We're looking for a result which makes us feel more comfortable. And from that result we will then look at the next match. But it would be premature to say that if we win we are close, and if we lose we are far away."
Atletico can at least take confidence from the fact their place in the last eight of the Champions League is assured, while Sevilla saw their European challenge ended in midweek by a surprise defeat to unfancied Leicester.
The Foxes will be Atletico's opponents in the quarter-finals but Simeone refuses to believe they will be pushovers, despite a season spent battling at the wrong end of the Premier League.
He said: "First of all they are a team who finished top of their group and were the league champions last year.
Read the full article on eurosport.co.uk: Diego Simeone insists Sevilla result will not define Atletico Madrid's season