In total there are five changes as Sergi Roberto, Samuel Umtiti, Jordi Alba, Andres Iniesta and Suarez all miss out.
Meanwhile Lucas Digna, Javier Mascherano, Denis Suarez, Turan and Andre Gomes all come in, which could lead to a return of the three at the back formation.
Barcelona come into the game after a dramatic win over Real Madrid in El Clasico, where Messi scored late on to secure a 3-2 victory.
The result put Barca top, level on points with Real but ahead on the head-to-head record.
However Madrid have a game in hand which means even if Barcelona win all of their remaining games they won't necessarily be crowned champions.
Read the full article on eurosport.co.uk: Enrique rests Suarez against Osasuna