Evans and Edmund have both become fixtures of Great Britain's Davis Cup team but they will face off against each other in Monte Carlo.
Nadal has a bye into the second round and he will face the victory of the clash between the two Brits.
The pair have only faced each other competitively on one other occasion, in the 2016 Challenger final in Dallas.
Edmund won that match 6-3, 6-2 and on clay he is already the favourite for some to repeat that victory.
Evans has seen his form drop off a bit after a stellar start to the year, defeating Bernard Tomic and Marin Cilic on his way to the last 16 of the Australian Open.
Read the original article on Eurosport: Evans and Edmund to face each other in Monte Carlo, winner faces Nadal