Giroud has been recalled to a place in the starting line-up by Wenger in place of Theo Walcott, while Danny Welbeck has to again settle for a place on the bench.
For Tottenham, Mousa Dembele is confined to the substitutes' bench along with Kyle Walker, with Kieran Trippier and Son Heung-min both starting as Spurs appear to move back to a four at the back formation.
Tottenham: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Dier, Wanyama, Son, Eriksen, Dele, Kane. Subs: Vorm, Walker, Wimmer, Dembele, Sissoko, Nkoudou, Janssen.
Read the full article on eurosport.co.uk: Giroud handed start for Arsenal, Dembele on bench for Tottenham