All games 15:00 BST unless stated otherwise.
Tottenham Hotspur: Harry Kane is expected to start after returning from an ankle injury as a sub last weekend against Watford. Victory Wanyama is fit again.
Bournemouth: Tyrone Mings is back from suspension. Dan Gosling and Junior Stanislas are both doubts.
Crystal Palace: Patrick van Aanholt could be involved after returning to training following an ankle injury. Loic Remy, Andros Townsend, Scott Dann, James Tomkins, Frazier Campbell, Connor Wickham and Pape Souare are all out.
Leicester City: Wes Morgan will miss out again whilst there are expected to be many changes from Craig Shakespeare ahead of the second-leg of the Champions League tie against Atletico Madrid.
Everton: The Toffees will welcome back Ashley Williams from suspension but Aaron Lennon and Muhamed Besic remain out as well as the long-term absentees Ramiro Funes Mori, Seamus Coleman and James McCarthy.
Burnley: Steven Defour is fit but Johann Berg Gudmundsson is still out as is Dean Marney.
Stoke City: Jack Butland is available again and could return for his first appearance in over a year. Jonathan Walters is a doubt whilst Joe Allen and Ibrahim Afellay are both out.
Hull City: Tom Huddlestone is back from suspension with Dieumerci Mbokani and Harry Maguire both pushing for places.
Sunderland: Seb Larsson begins his three-match suspension but Adnan Januzaj returns after being able to face parent club Manchester United. John O'Shea also returns after personal leave following the death of his father but Bryan Oviedo misses out.
West Ham: Michail Antonio has been ruled out for the rest of the season and captain Mark Noble is suspended but Andy Carroll, Aaron Creswell and Sam Byram are all fit.
Read the full article on eurosport.co.uk: Weekend Premier League team news - De Gea to start