Paulo Dybala and Mario Mandzukic also scored for treble-chasing Juve, who never looked back after Genoa defender Ezequiel Munoz gifted them the lead with an own goal.
Substitute Arkadiusz Milik rescued a 2-2 draw for third-placed Napoli after a topsy-turvy second half at Sassuolo where they led 1-0, gifted an equaliser and then hit the woodwork twice.
Lazio's Keita Balde Diao scored a six-minute hat-trick as they hit five goals in the first half-hour on the way to a 6-2 demolition of sorry Palermo and AC Milan suffered a shock 2-1 home defeat by lowly Empoli.
Sampdoria's Patrik Schick provided another highlight with a superb effort against Crotone when he flicked the ball up and turned past two defenders, ran on and scored with a clinical finish. However the visitors hit back to win 2-1.
Juventus, who have 83 points from 33 games, moved 11 clear of AS Roma who visit basement club Pescara on Monday.
Napoli are a further point behind in the Champions League playoff-round spot on 71 points, with Lazio fourth while Milan, despite their slip-up, stayed sixth on 58 points in the last Europa League place two points above city rivals Inter.
Struggling Genoa were quickly in trouble at Juventus when when home striker Gonzalo Higuain's chipped pass bounced off Munoz's shin and into the net in the 17th minute.
A minute later, Dybala played a one-two with Sami Khedira and sent an unstoppable shot past goalkeeper Eugenio Lamanna for the second while Mandzukic added the third with a brilliant side-footed volley five minutes before halftime.
Not be outdone, Bonucci collected the ball in the centre circle, burst through the Genoa midfield and scored with a vicious, dipping shot from outside the penalty area in the 64th.
Napoli went ahead when Dries Mertens headed in from Jose Callejon's cross in the 52nd minute to delight the army of shirtless visiting fans behind the goal.
A mistake by Napoli's usually inspirational captain Marek Hamsik allowed Sassuolo to level seven minutes later when Domenico Berardi intercepted the Slovakian's headed back pass and fired past Pepe Reina.
Read the full article on eurosport.co.uk: Bonucci solo goal caps crushing Juve win over Genoa