Seamus Coleman suffered a nasty injury and Wales’ Neil Taylor was shown a straight red card as the Republic of Ireland and Wales played out a goalless draw in Dublin.
The injury, which came midway through the second half, drew immediate concern from both sets of players, with Shane Long immediately going to console his team-mate as Coleman received treatment from the Irish medical staff.
The challenge came minutes after Gareth Bale had been shown a yellow card for a late challenge of his own and that booking will rule him out of the game against Serbia, a match that is crucial for the Welsh now.
For most of the game it was Bale who looked as if he would break the deadlock. The Real Madrid man was everywhere and kept trying clever passes or ambitious shots. However it didn't quite come off for him, perhaps suggesting that he isn't still fully match fit following a long lay-off.
After Coleman's injury and Taylor's red card, Ireland took control and started to pepper the Wales penalty area with as much pressure as they could muster.
Ultimately though Wayne Hennessey wasn't forced to make a big save - indeed the Welsh keeper caused the biggest moment of panic when he dropped the ball under no pressure, although fortunately for him Ashley Williams was on hand to clear.
REACTION TO COLEMAN INURY
Republic of Ireland manager Martin O'Neill: "He's a fantastic player and character," said O'Neill on Sky Sports. "It's a major blow for the lad, his club and us.
"Apparently it wasn't the best challenge in the world.I haven't seen it. He's gone to hospital. I saw his reaction immediately and it didn't look good.
"He was holding his leg up and it didn't look good. At the end of it all, the most important thing is Seamus' health."
Wales manager Chris Coleman: "First and foremost, the most important thing is Seamus Coleman.
"We are told that it is not so good, which we are sorry for.
"Neil Taylor is not really that type of player, but it's a tough one for Seamus. Our thoughts are with him. I have not seen it again."
Read the full article on eurosport.co.uk: Coleman suffers horror leg break as Ireland and Wales play out stalemate