Defoe's age has regularly counted against him when international squads have been named, but a combination of his own good form and a number of striking injuries saw him called up by Gareth Southgate. Jamie Vardy, who led the line against Germany, drops to the bench.
Elsewhere Joe Hart captains the side in place of the absent Wayne Rooney and Gary Cahill, with Kyle Walker, Ryan Bertrand John Stones and Michael Keane, who makes his competitive England debut, named in defence.
Eric Dier is joined in midfield by Alex Oxlade-Chamberlain, with Raheem Sterling, Dele Alli and Adam Lallana behind Defoe.
That means that there are four changes from the 1-0 defeat to Germany, with Stones, Oxlade-Chamberlain, Sterling and Defoe replacing Cahill, Chris Smalling, Jake Livermore and Vardy.
Read the full article on eurosport.co.uk: Defoe leads England against Lithuania