The sportswear giant take over from Le Coq Sportif and will be the official and recognised technical partner on all of Everton's match and training kits.
Everton's new deal, negotiated in close collaboration with their retail and merchandise partner Kitbag, is the first with Nike.
"We're all excited by the prospect of working with Nike's design, marketing and retailing teams," said Toffees chief executive Robert Elstone.
"We look forward to seeing some impressive, original kits and products, as well as being on hand to take advantage of new retail opportunities that we'll be working with Kitbag to drive forward.
"Nike has an impeccable reputation and we are confident that our supporters will be excited by the new partnership, with all of us looking forward to seeing our new home shirt this summer."