Chelsea visit Goodison Park hoping to solidify their place in the top four after getting back to winning ways against Aston Villa in midweek.
Duncan Ferguson has been placed in interim charge and will be hoping to secure a win after three disappointing defeats in succession.
Tammy Abraham is likely to be fit for a second successive start for the visitors, who may be without Yerry Mina.
Here is everything you need to know about the Premier League clash.
Everton win 13/5
Chelsea win EVENS
Everton come into this game desperate to arrest their slide after slipping into the bottom three, but interim manager Duncan Ferguson has quite the job on his hands with a short turnaround before a game against a confident Chelsea side.
The visitors should pick up the three points away from home. Everton 1-3 Chelsea is our prediction.
When is it?
Kick-off at Goodison Park is at 12.30pm GMT.
How can I watch it?
The match will be aired live on BT Sport 1, with coverage beginning at 12pm.
BT Sport customers can watch the game via the online player or via the BT Sport app.
Everton are set to continue to be without midfielder Fabian Delph and captain Seamus Coleman, while interim manager Duncan Ferguson may also be unable to call upon centre-half Yerry Mina, who picked up a knock against Liverpool.
Tammy Abraham is likely to be fit despite leaving the pitch in pain against Aston Villa this week. Ross Barkley should return to the squad with illness, while Antonio Rudiger is moving closer to action after a longer-term injury absence.
Everton XI: Jordan Pickford; Djibril Sidibe, Mason Holgate, Michael Keane, Lucas Digne; Tom Davies, Morgan Schneiderlin; Alex Iwobi, Gylfi Sigurdsson, Richarlison; Dominic Calvert-Lewin.
Chelsea XI: Kepa; Reece James, Kurt Zouma, Fikayo Tomori, Cesar Azpilicueta; N’Golo Kante, Jorginho, Mason Mount; Willian, Tammy Abraham, Christian Pulisic.