The Saints haven’t secured a victory in any of their last seven top-flight fixtures, having lost six of them to drop to 14th in the table.
Ralph Hasenhuttl’s side were beaten 3-0 by Leeds last time out, while Everton were 2-0 winners at Anfield in the Merseyside derby against rivals Liverpool.
Richarlison and Gylfi Sigurdsson were the goalscorers for Carlo Ancelotti’s team in that historic win, which positioned the Toffees seventh in the Premier League.
Here’s everything you need to know about tonight’s clash.
When is it?
The game kicks off at 8pm GMT this evening.
How can I watch it?
The match will air live on Sky Sports Premier League and Sky Sports Main Event, with subscribers also able to stream it live on the Sky Sports website and SkyGo app.
Everton: Pickford, Godfrey, Holgate, Digne, Keane, Allan, Gomes, Doucoure, Sigurdsson, Richarlison, Calvert-Lewin
Southampton: Forster, Bertrand, Salisu, Bednarek, Vestergaard, Ward-Prowse, Djenepo, Armstrong, Redmond, Adams, Ings
Everton 2-1 Southampton.