Carlos Ancelotti takes on Ralph Hasenhuttl here in one of the most interesting managerial battles this week. While Danny Ings, on 18 goals so far this season, is looking to win the Premier League golden boot, with Jamie Vardy four goals ahead on 22 goals.
Follow all the updates and reaction from Goodison Park here.
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When is it and what time is kick-off?
The match will begin at 6pm on Thursday 9 July at Goodison Park.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
Everton are waiting anxiously on the fitness of Alex Iwobi and Mason Holgate. Theo Walcott, Jean-Philippe Gbamin, Fabian Delph and Cenk Tosun are all ruled out. Djibril Sidibe could return.
Southampton are without Jannik Vestergaard and Yan Valery, while Moussa Djenepo and Nathan Tella are also doubts. Sofiane Boufal and Pierre-Emile Hojbjerg are both set to return.
Everton: Pickford; Sidibe, Keane, Mina, Digne; Sigurdsson, Davies, Gomes, Gordon; Richarlison, Calvert-Lewin
Southampton: McCarthy; Walker-Peters, Stephens, Bednarek, Bertrand; Armstrong, Ward-Prowse, Hojbjerg, Redmond; Ings, Adams
What are the odds?
Everton – 11/10
Draw – 5/2
Southampton – 12/5