FA Cup holders Manchester City will host Championship side Fulham in the fourth round of the competition following the draw on Monday evening.
Premier League leaders Liverpool will face an away trip to either Bristol City of the Championship or Shrewsbury of League One.
Tranmere Rovers, who came back to draw against Watford in spectacular fashion will be rewarded with plum home tie against the winner of the replayed match between Wolves and Manchester United, should they come through their own replay at Prenton Park.
Northampton Town, the lowest ranked team left in the competition were drawn against Derby, complete with new singing Wayne Rooney.
Arsenal travel Bournemouth after beating Leeds while Chelsea are handed a trip to Hull.
Watford/Tranmere Rovers v Wolves/Manchester United
Hull City v Chelsea
Southampton v Middlesbrough/Tottenham
Queens Park Rangers v Sheffield Wednesday
Bournemouth v Arsenal
Northampton v Derby County
Brentford v Leicester City
Millwall v Sheffield United
Reading/Blackpool v Cardiff City/Carlisle United
West Ham United v West Bromwich Albion
Burnley v Norwich City
Bristol Rovers/Coventry City v Birmingham City
Manchester City v Fulham
Rochdale/Newcastle United v Oxford United
Portsmouth v Barnsley
Bristol City/Shrewsbury Town v Liverpool