Uwe Rosler's Latics beat Manchester City in last year's final before overcoming the odds to once again beat City at the quarter-final stage on Sunday.
They return to Wembley to take on the Gunners, who are looking for their first trophy since lifting the FA Cup nine years ago with a penalty shoot-out victory over Manchester United at the Millennium Stadium.
Arsenal had seen off the challenge of Everton, managed by ex-Wigan boss Roberto Martinez, in their last-eight clash and will be looking to ease past Wigan in their 5pm kick-off to book their place in the Wembley final on May 17.
Sheffield United beat Charlton in the sixth round on Saturday and Bruce's Hull were victorious against Barclays Premier League rivals and beaten Capital One Cup finalists Sunderland.
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