David Moyes takes what is likely to be a rotated side to Romania, having safely secured passage into the last 16 and thereby skipping the next round.
FCSB, however, did give a good account of themselves during the reverse fixture that seems like an age ago now, and will be licking their lips at the prospect of playing a weakened Hammers side.
Still, with plenty of players looking to make a case for regular involvement in east London, those coming into the team will want to ensure the good feeling at the club continues.
Here’s how to watch the action live tonight.
Where to watch FCSB vs West Ham
TV channel: The game will be broadcast on BT Sport 3.
Live stream: BT Sport subscribers will be able to watch the game via the BT Sport website or app.