Kagawa is one of the few certainties in the travelling party after Ferguson's summer plans were hit by the need to rest players after Euro 2012 and also the departures of others, including Ryan Giggs and David de Gea, for Olympic duty.
The Red Devils are also supplying three players to England's European Under-19 Championship quest, while Nemanja Vidic and Chris Smalling will not be considered due to injury and Darren Fletcher is due to begin the first tentative stages of his comeback from a chronic bowel complaint.
The pressures on his squad means Ferguson is unlikely to know until the eve of departure exactly who will be on the flight to Durban on July 16. Kagawa will be there, though, offering United fans the first opportunity to see him in action since his summer move from Borussia Dortmund, as will fellow new boy Nick Powell, who has signed from Crewe.
Ferguson said: "It's obviously very difficult in a year when we have had a Euro tournament and we also have the Olympics this year. The final squad hasn't been decided yet but we will be taking the strongest team we have available. We are all looking forward to the pre-season tour.
"I am delighted that our new newest signings, Shinji Kagawa and Nick Powell, will be in the travelling squad along with more established players such as Rio Ferdinand, Michael Carrick and Ji Sung-Park."