The American group took over at Anfield in October 2010 having had no previous experience of the sport, with the Boston Red Sox baseball team its primary interest.
FSG initially canvassed advice from a wide range of sources - many of whom have never been named - but Ayre said it was part of the learning process.
Things have changed since then, with Ayre pointing to transfer strategy as the most significant area after accepting they could not be successful taking decisions on the "whim" of any one individual.
"There were two phases to what's happened since the change of ownership," Ayre told Sports Illustrated.
"In the first phase we talked about the knowledge of soccer and that takes time so we probably spent a year with the owners taking a leap of faith to a certain degree of other people telling them what they should be doing.
"Within that year we then get to a situation where the dust has settled and people start to see what is and isn't working.
"I think the fundamental shift particularly around player acquisitions and disposals was that we took the view that it needs to be more of a science.
"Your biggest expenditure line can't be the whim of any individual."
- Sports & Recreation